Optogenetic Control of Mouse Outer Hair Cells
نویسندگان
چکیده
منابع مشابه
Optogenetic Control of Mouse Outer Hair Cells.
Normal hearing in mammals depends on sound amplification by outer hair cells (OHCs) presumably by their somatic motility and force production. However, the role of OHC force production in cochlear amplification and frequency tuning are not yet fully understood. Currently, available OHC manipulation techniques for physiological or clinical studies are limited by their invasive nature, lack of pr...
متن کاملCochlear amplification, outer hair cells and prestin.
Mechanical amplification of acoustic signals is apparently a common feature of vertebrate auditory organs. In non-mammalian vertebrates amplification is produced by stereociliary processes, related to the mechanotransducer channel complex and probably to the phenomenon of fast adaptation. The extended frequency range of the mammalian cochlea has probably co-evolved with a novel hair cell type, ...
متن کاملModeling wave interactions between outer hair cells
6.1 The basics of wave propagation 6.1/a Effects of changes in standard parameters 6.2 Feedback between outer hair cells 6.2/a Feedback topology 6.2/b Response of three rows of cells 6.3 Modeling squirting wave excitation of the OHC array 6.3/a Explicit solution of the many-cell problem: full wavelength resonance Results and derivations 6.3/b Explicit solution of the many-cell problem: half-wav...
متن کاملSensory transduction and adaptation in inner and outer hair cells of the mouse auditory system.
Auditory function in the mammalian inner ear is optimized by collaboration of two classes of sensory cells known as inner and outer hair cells. Outer hair cells amplify and tune sound stimuli that are transduced and transmitted by inner hair cells. Although they subserve distinct functions, they share a number of common properties. Here we compare the properties of mechanotransduction and adapt...
متن کاملActivity-dependent regulation of prestin expression in mouse outer hair cells.
Prestin is a membrane protein necessary for outer hair cell (OHC) electromotility and normal hearing. Its regulatory mechanisms are unknown. Several mouse models of hearing loss demonstrate increased prestin, inspiring us to investigate how hearing loss might feedback onto OHCs. To test whether centrally mediated feedback regulates prestin, we developed a novel model of inner hair cell loss. In...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.11.3521